Our ”Sequence Blender” protein evolution technology can be adapted to any recombinant enzyme expressed in bacteria or yeast cells to improve its specific parameters – substrate specificity, resistance to temperature or other environmental factors etc.
Custom services include:
Improvement of desired properties of biocatalysts. Construction of a library of mutant enzymes and search for a biocatalyst with the desired property.
Custom library construction. Construction of DNA fragments library OR plasmid library OR clone library, containing mutations listed by the customer.
Arranging customers library. Seeding individual clones from a customer plasmid library and arranging them in 96 or 384-well format.
Screening of custom libraries
Metkinen Chemistry know-how is not technical improvements of the methods exploited by the competitors, but rather a ride on the rising wave of proteome research, instead of the weakening wave of genome research.
Metkinen Chemistry mutagenesis method "Smart codon permutator" is based on the rational selection of gene sites to be mutated and chemical synthesis of representative oligo libraries.
MetGen proprietary Smart Codon Permutator and Sequence Blender Technology provide significant advantage over existing approaches in regards to selectivity, productivity and eventually costs of desired industrial enzymes or microorganisms.
