Modified nucleosides are classical antiviral drugs used in the treatment of the herpes virus and HIV. Close to 100 nucleosides and nucleoside analogs are commercial and in the pipeline. Sales of nucleosides and nucleoside analogs are more than $8 billion. A large number of modified nucleosides are approved as antiviral agent as well as antitumor agents. However, preparation of these compounds remains laborious and a highly expensive multi-step chemical procedure. The solution for this problem is developing bioconversion method replacing conventional chemical procedureMetGen Nucleoside Conversion Toolbox is a panel of recombinant mutant transglycosilation enzymes, including Uridine ,Tymidine and Purine Nucleotide Phosphorylases for bioconversion of modified nucleosides.
MetGen Nucleoside Conversion Toolbox is the best choice for various unnatural substrates such as fluorinated and aminated nucleosides.
MetGen FlexyZyme is a phosphorylase with extremely high tolerance to mutations even in the most conserved regions, including the enzyme’s active cite. This enzyme displays good PNP activity and is used as a template for mutagenesis in custom projects on enzyme structure optimization. Subject for IPR.
MetGen offers development of custom biotransformation processes for:
Small molecule drugs ( i.e modified nucleosides)
Protein molecules with high affinity to specific bio-molecules (i.e synthetic therapeutic antibodies, inhibitory peptides)
Close cooperation with pharma companies on each stage of drug development process
Drug discovery: Estimation of feasibility of therapeutic nucleoside analogs synthesis via biotransformation.
Preclinical : Development of evolved enzymes adopted to the desired substrate. Production of sufficient quantities of exceptionally pure and BSE/TSE risk free therapeutic nucleosides, prepared via biotransformation.
Clinical trials: Multi-kilo scale up of therapeutic nucleoside preparation process
Drug manufacturing: Cost-effective, efficient and environmentally friendly enzyme based production processes
